Drosophila recombinant population (DRP) resource for investigating genetic basis of complex traits
We have recently developed a Drosophila recombinant population (DRP) resource for investigating genetic basis of complex traits. The fruit fly Drosophila is a well-established model for genetic studies, and it provides powerful tools for dissecting the contributions of both genes and environment. We created a multi-parental advanced intercross mapping resource, which comprises 16 highly recombinant synthetic fly populations each founded by eight inbred lines derived from a natural population. The experimental system is designed to increase the power to detect associated variants and to boost the frequency of rare alleles.
This mapping approach exhibits favorable sensitivity and resolution with a low false positive discovery rate.